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DHA & Pregnancy

Improves Child IQ & Mental Processing

DHA & Pregnancy

Docosahexaenoic Acid (DHA) is an omega-3 fatty acid representing more than 90% of omega-3 fatty acids in the brain and retina. DHA is particularly important during the 3rd trimester of pregnancy through to breastfeeding, and is proven to play a significant role in fetal: brain, cognitive, visual, nervous, and motor skill development.

During pregnancy and breastfeeding when rapid fetal brain and central nervous system development occurs, DHA requirements increase significantly. Inadequate intake of dietary or supplemental DHA can deprive you and your child of much-needed DHA for optimal development.

DHA is available in two forms – Triglyceride (TG) or Ethyl Ester (EE). TG DHA is the natural triglyceride form found in food and fish, whereas EE DHA is the potentially toxic ethanol (alcohol) form. Unlike EE DHA which has an ethyl ester backbone, TG DHA has a natural glycerol backbone offering superior absorption without the risk of toxicity.

Manufacturing a highly-concentrated DHA oil requires the temporary separation of the glycerol backbone. Once further processing has been completed and a highly-concentrated DHA oil has been produced, either a glycerol backbone or an ethyl ester backbone can be added. Due to the high cost of restoring the original triglyceride structure which is only achievable by adding a glycerol backbone, most manufacturers use an ethyl ester backbone by reacting the DHA oil with ethanol.

The source of DHA is also very important, as DHA can be extracted either from fish (fish-based DHA) or plants (plant-based DHA). Leading research suggests that fish-based DHA is superior and does not contain Alpha-Linolenic Acid (ALA) – an omega-3 fatty acid only found in plants. ALA does not offer the health benefits of DHA and other omega-3 fatty acids; particularly during pregnancy and breastfeeding, and is poorly converted from ALA to DHA, with an estimated conversion rate of only 2%-3%.

Introducing UltraDHA™ (TG DHA Omega-3 Oil) - the purest and highest quality TG DHA omega-3 oil available. UltraDHA™ (TG DHA Omega-3 Oil) is a fish-based DHA oil containing an original triglyceride structure. TG DHA is proven to be up to 70% more bioavailable than regular EE DHA.

Triglyceride DHA vs Ethyl Ester DHA

DHA supplementation during pregnancy and breastfeeding is also proven to increase the IQ of children at 4-years of age. Specifically, a correlation between mental processing skills and head circumference has been identified, and an inadequate supply of DHA during pregnancy and throughout lactation may result in a smaller head circumference.

Women with low levels of DHA and omega-3 fatty acids are also 7.6 times more likely to experience pregnancy complications such as preeclampsia. A small 15% increase in the ratio of omega-3 to omega-6 fatty acids can reduce the chances of preeclampsia by up to 46%; highlighting the importance of supplementing with UltraDHA™ (DHA Omega-3 Oil) to increase and sustain your breast milk DHA levels during pregnancy and throughout lactation.

Vertili™ is formulated with 400mg of UltraDHA™ (TG DHA Omega-3 Oil) per serving - 200% of the RDI for pregnant women; providing your body with an ultra-pure DHA oil which is vital during pregnancy and breastfeeding.

References

  1. Birch, E.E., et al., A randomized controlled trial of long-chain polyunsaturated fatty acid supplementation of formula in term infants after weaning at 6 wk of age. Am J Clin Nutr, 2002. 75(3): p. 570-80.
  2. Smuts, C.M., et al., A randomized trial of docosahexaenoic acid supplementation during the third trimester of pregnancy. Obstet Gynecol, 2003. 101(3): p. 469-79.
  3. Nordoy, A., et al., Absorption of the n-3 eicosapentaenoic and docosahexaenoic acids as ethyl esters and triglycerides by humans. Am J Clin Nutr, 1991. 53(5): p. 1185-90.
  4. Makrides, M., et al., Are long-chain polyunsaturated fatty acids essential nutrients in infancy? Lancet, 1995. 345(8963): p. 1463-8.
  5. Dyerberg, J., et al., Bioavailability of marine n-3 fatty acid formulations. Prostaglandins Leukot Essent Fatty Acids, 2010. 83(3): p. 137-41.
  6. Birch, E., et al., Breast-feeding and optimal visual development. J Pediatr Ophthalmol Strabismus, 1993. 30(1): p. 33-8.
  7. Beckermann, B., M. Beneke, and I. Seitz, [Comparative bioavailability of eicosapentaenoic acid and docasahexaenoic acid from triglycerides, free fatty acids and ethyl esters in volunteers]. Arzneimittelforschung, 1990. 40(6): p. 700-4.
  8. Innis, S.M., et al., Development of visual acuity in relation to plasma and erythrocyte omega-6 and omega-3 fatty acids in healthy term gestation infants. Am J Clin Nutr, 1994. 60(3): p. 347-52.
  9. Birch, E.E., et al., Dietary essential fatty acid supply and visual acuity development. Invest Ophthalmol Vis Sci, 1992. 33(11): p. 3242-53.
  10. Visioli, F., et al., Dietary intake of fish vs. formulations leads to higher plasma concentrations of n-3 fatty acids. Lipids, 2003. 38(4): p. 415-8.
  11. Jensen, C.L. and A. Lapillonne, Docosahexaenoic acid and lactation. Prostaglandins Leukot Essent Fatty Acids, 2009. 81(2-3): p. 175-8.
  12. Fidler, N., et al., Docosahexaenoic acid transfer into human milk after dietary supplementation: a randomized clinical trial. J Lipid Res, 2000. 41(9): p. 1376-83.
  13. Jensen, C.L., et al., Effect of docosahexaenoic acid supplementation of lactating women on the fatty acid composition of breast milk lipids and maternal and infant plasma phospholipids. Am J Clin Nutr, 2000. 71(1 Suppl): p. 292S-9S.
  14. Futterman, S., J.L. Downer, and A. Hendrickson, Effect of essential fatty acid deficiency on the fatty acid composition, morphology, and electroretinographic response of the retina. Invest Ophthalmol, 1971. 10(2): p. 151-6.
  15. Ramakrishnan, U., et al., Effects of docosahexaenoic acid supplementation during pregnancy on gestational age and size at birth: randomized, double-blind, placebo-controlled trial in Mexico. Food Nutr Bull, 2010. 31(2 Suppl): p. S108-16.
  16. Jensen, C.L., et al., Effects of maternal docosahexaenoic acid intake on visual function and neurodevelopment in breastfed term infants. Am J Clin Nutr, 2005. 82(1): p. 125-32.
  17. Jensen, C.L., et al., Effects of maternal docosahexaenoic acid supplementation on visual function and growth of breast-fed term infants. Lipids, 1999. 34 Suppl: p. S225.
  18. el Boustani, S., et al., Enteral absorption in man of eicosapentaenoic acid in different chemical forms. Lipids, 1987. 22(10): p. 711-4.
  19. Makrides, M., et al., Erythrocyte docosahexaenoic acid correlates with the visual response of healthy, term infants. Pediatr Res, 1993. 33(4 Pt 1): p. 425-7.
  20. Horrocks, L.A. and Y.K. Yeo, Health benefits of docosahexaenoic acid (DHA). Pharmacol Res, 1999. 40(3): p. 211-25.
  21. Smithers, L.G., et al., Higher dose of docosahexaenoic acid in the neonatal period improves visual acuity of preterm infants: results of a randomized controlled trial. Am J Clin Nutr, 2008. 88(4): p. 1049-56.
  22. Lawson, L.D. and B.G. Hughes, Human absorption of fish oil fatty acids as triacylglycerols, free acids, or ethyl esters. Biochem Biophys Res Commun, 1988. 152(1): p. 328-35.
  23. Reece, M.S., et al., Maternal and perinatal long-chain fatty acids: possible roles in preterm birth. Am J Obstet Gynecol, 1997. 176(4): p. 907-14.
  24. Helland, I.B., et al., Maternal supplementation with very-long-chain n-3 fatty acids during pregnancy and lactation augments children's IQ at 4 years of age. Pediatrics, 2003. 111(1): p. e39-44.
  25. Salem, N., Jr., et al., Mechanisms of action of docosahexaenoic acid in the nervous system. Lipids, 2001. 36(9): p. 945-59.
  26. Escolano-Margarit, M.V., et al., Prenatal DHA status and neurological outcome in children at age 5.5 years are positively associated. J Nutr, 2011. 141(6): p. 1216-23.
  27. Olsen, S.F., et al., Randomised clinical trials of fish oil supplementation in high risk pregnancies. Fish Oil Trials In Pregnancy (FOTIP) Team. BJOG, 2000. 107(3): p. 382-95.
  28. Kulkarni, A.V., et al., Reduced placental docosahexaenoic acid levels associated with increased levels of sFlt-1 in preeclampsia. Prostaglandins Leukot Essent Fatty Acids, 2011. 84(1-2): p. 51-5.
  29. Olafsdottir, A.S., et al., Relationship between dietary intake of cod liver oil in early pregnancy and birthweight. BJOG, 2005. 112(4): p. 424-9.
  30. Crawford, M.A., The role of essential fatty acids in neural development: implications for perinatal nutrition. Am J Clin Nutr, 1993. 57(5 Suppl): p. 703S-709S; discussion 709S-710S.
  31. Allen, K.G. and M.A. Harris, The role of n-3 fatty acids in gestation and parturition. Exp Biol Med (Maywood), 2001. 226(6): p. 498-506.
  32. Koletzko, B., et al., The roles of long-chain polyunsaturated fatty acids in pregnancy, lactation and infancy: review of current knowledge and consensus recommendations. J Perinat Med, 2008. 36(1): p. 5-14.
  33. Malcolm, C.A., et al., Scotopic electroretinogram in term infants born of mothers supplemented with docosahexaenoic acid during pregnancy. Invest Ophthalmol Vis Sci, 2003. 44(8): p. 3685-91.
  34. Helland, I.B., et al., Supplementation of n-3 fatty acids during pregnancy and lactation reduces maternal plasma lipid levels and provides DHA to the infants. J Matern Fetal Neonatal Med, 2006. 19(7): p. 397-406.
  35. Martinez, M., Tissue levels of polyunsaturated fatty acids during early human development. J Pediatr, 1992. 120(4 Pt 2): p. S129-38.
  36. Innis, S.M., et al., Visual acuity and blood lipids in term infants fed human milk or formulae. Lipids, 1997. 32(1): p. 63-72.
  37. Jorgensen, M.H., et al., Visual acuity and erythrocyte docosahexaenoic acid status in breast-fed and formula-fed term infants during the first four months of life. Lipids, 1996. 31(1): p. 99-105.
  38. Carlson, S.E., et al., Visual acuity and fatty acid status of term infants fed human milk and formulas with and without docosahexaenoate and arachidonate from egg yolk lecithin. Pediatr Res, 1996. 39(5): p. 882-8.
  39. Birch, E.E., et al., Visual acuity and the essentiality of docosahexaenoic acid and arachidonic acid in the diet of term infants. Pediatr Res, 1998. 44(2): p. 201-9.
  40. Courage, M.L., et al., Visual acuity development and fatty acid composition of erythrocytes in full-term infants fed breast milk, commercial formula, or evaporated milk. J Dev Behav Pediatr, 1998. 19(1): p. 9-17.
  41. Hoffman, D.R., et al., Visual function in breast-fed term infants weaned to formula with or without long-chain polyunsaturates at 4 to 6 months: a randomized clinical trial. J Pediatr, 2003. 142(6): p. 669-77.
  42. Birch, E.E., et al., Visual maturation of term infants fed long-chain polyunsaturated fatty acid-supplemented or control formula for 12 mo. Am J Clin Nutr, 2005. 81(4): p. 871-9.
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